MARTINDALE’S THE “VIRTUAL” – PHARMACY, PHARMACOLOGY & TOXICOLOGY CENTER PHARMACOLOGY & CLINICAL PHARMACOLGY |
|
Home Page ~
Pharmacy, Pharmacology & Toxicology Center
Clinical Pharmacology Clinical Pharmacology Courses with Text, Images, Videos/Movies & Audio/Sound
medical schools lack a formal course in training for clinical research, and investigators have relied on mentors to learn how to conduct clinical trials…” Examples of “Introduction to the Principles and Practice of Clinical Research (IPPCR) Chapters include
Ethical Issues in Human Subjects Research; Monitoring Patient Oriented Research and Regulatory Issues; Preparing and Funding a Clinical Research Study…” For more information see
to take the certifying examinations of the American Board of Clinical Pharmacology and to meet the needs of researchers who have an interest in the clinical pharmacologic aspects of contemporary drug development and utilization…” Examples of “Principles of Clinical Pharmacology” Course Categories & Subcategories include
Compartmental analysis of drug distribution; Drug absorption and bioavailability; Effects of liver disease on pharmacokinetics; Population pharmacokinetics; etc…” Drug Metabolism & Transport
Drug interactions; Equilibrative and concentrative transport; etc…” Assessment of Drug Effects
Physiological and laboratory markers of drug effect; etc…” Optimizing and Evaluating Patient Therapy
Drug therapy in the elderly; etc…” Drug Discovery and Development
Pre-clinical drug development; Animal scale up and Phase I studies; Pharmacokinetics of biotechnology products and large molecules; etc…” For more information see |
Anatomy Related Centers FOR HUMAN ANATOMY ATLASES, CASES, COURSES, DATABASES, JOURNALS, TEXTBOOKS, LESSONS, VIDEOS, ETC. SEE THE FOR ANIMAL ANATOMY ATLASES, CASES, COURSES, DATABASES, JOURNALS, TEXTBOOKS, LESSONS, VIDEOS, ETC. SEE THE Cardiovascular Pharmacology Lectures, Lessons, etc. with Text, Images, Simulations, Videos/Movies & Audio/Sound
Blumenthal’s pharmacology course detailing bloodflow, aortic/ventricular volumes and pressures present in a normal cardiac cycle. Also included are an electrocardiogram and heart sounds graph…” For more information see Cardiovascular & Cardiopulmonary Physiological Model
four-chamber varying-elastance heart, a pericardium, a systemic circulation, a pulmonary circulation, a coronary circulation, airways mechanics, baroreceptors, and gas exchange…” For more information see
in the internal radius of a thick-walled, distensible, isotropic, cylindrical vessel. Reference pressures and volumes are tunable…”
resistance to flow R and compliance of the vessel, C, derived from a thin walled formulation of vessel wall mechanics…” Related Dermatological Pharmacology Centers FOR DERMATOLOGY ATLASES, CASES, COURSES, DATABASES, JOURNALS, TEXTBOOKS, LESSONS, VIDEOS, ETC. SEE THE |
DRUG METABOLISM, SINGLE NUCLEOTIDE POLYMORPHISM, ETC. Related Centers PRESCRIPTION & OVER-THE-COUNTER DRUG DATABASES, ETC. SEE FOR MORE THAN 200 RELATED DATABASES INCLUDING CHMICAL COMPUNDS, Drug Target & Drug Data
that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, pathway) information. DrugBank Database
small molecule drugs, 113 FDA-approved biotech (protein/peptide) drugs, 62 nutraceuticals and >3,000 experimental drugs. Additionally, more than 6,000 protein (i.e. drug target) sequences are linked to these drug entries…” For more information see Drug Metabolism Drug Metabolism Databases
specific cytochrome P450 isoform are the published inhibitors, inducers and genetic influences on that isoform…” Examples of “Drug Interaction Table: Cytochrome P450 Drug Interaction” Categories & Subcategories include
Anti-epileptics; NSAID; Oral Hypoglycemic Agents; Angiotensin II Blockers; Sulfonylureas; Beta Blockers; Antidepressants; Antipsychotics; Anesthetics; Macrolide Antibiotics; Benzodiazepines; Immune Modulators; HIV Antivirals; Calcium Channel Blockers; etc…” Inhibitors
thus affecting the optimal level of metabolism of the substrate drug which in many cases affect the individual’s response to that particular medication, e.g. making it ineffective…” Inducers
increasing the rate of metabolism causing the substrate drug to clear out of the system faster. This will also affect the individual’s response to the medication, i.e. making he drug ineffective…” For more information see
domain which provides information on the abilities of drugs to interact with an expanding number of molecular targets…” PDSP Ki Database
For more information see |
Drug Chemical Structures
n Vivo screening summary data; Browse cancer screening data; Basic chemical data; Chemical names; Smiles search; Search NCI60 molecular target characterization data; Search DTP Plate Map; Search Sarcoma Project Data; Search Yeast Screening Data; etc…” For more information see
calculates on-the-fly various drug-relevant properties whenever a structure is valid. Prediction results are valued and color coded…” Examples of Specific information about individual properties include
cLogP Prediction; Solubility Prediction; Molecular Weights; Fragment-based Drug-Likeness Prediction; Overall Drug-Likeness Score, etc…” For more information see
text drawing) and from it generate a variety of topologies for use with GROMACS, WHAT IF, Autodock, HEX, CNS…” For more information see Drug Likeness & Molecular Property Prediction
fragment-based contributions…” For more information see
molecular polar surface area PSA, rule of 5 parameters or drug likeness…” For more information see Single Nucleotide Poloymorphism
The National Center for Biotechnology Information has established the dbSNP database to serve as a central repository for both single base nucleotide subsitutions and short deletion and insertion polymorphisms. Once discovered, these polymorphisms could be used by additional laboratories, using…” Single Nucleotide Poloymorphism Submission Information by
New Batches; Method; Population; Publication…” For more information see |
Haplotypes
used in the quantitative assessment of matches in forensic and kinship casework….” “…Assessment of male population stratification among world-wide populations as far as reflected by Y-STR and Y-SNP frequency distributions….”
Ion Channels
Gap junctions; Long QT Syndromes; Potassium; K+/H+ ATPase; Sodium; Sodium/Hydrogen Exchangers; Toxins…” Channel Binding Proteins; For more information see
Molecular Movements Databases Molecular Movements Databases with Text, Images & Videos/Movies
macromolecules (such as RNA). Associated with it are a variety of free software tools for structural analysis…” For more information see the Protein Fold Recognition Protein Fold Recognition Databases with Text, Images & Videos/Movies
using 1D and 3D Sequence Profiles coupled with Secondary Structure and Solvation Potential Information…” For more information see |
Receptors Receptor Nomenclature and Drug Classification
IUPHAR Receptor Code; IUPHAR Receptor List & Terms and Symbols…” For more information see the G Protein-Coupled Receptors
Olfactory Receptors
for investigators to analyse the functions of these very large gene families of G protein-coupled receptors…” For more information see the |
Chemistry Related Centers FOR CHEMISTRY ATLASES, CASES, COURSES, DATABASES, JOURNALS, TEXTBOOKS, VIDEOS, ETC. SEE THE Medicinal Chemistry Courses & Lectures ANALYTICAL MEDICINAL CHEMISTRY (FLASH) – Longqin Hu, Department of Pharmaceutical Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey Multimedia Analytical Medicinal Chemistry Course (Text & Images). VERY VERY VERY…EXTENSIVE. Examples of “Analytical Medicinal Chemistry” Course Lectures include
Applications of LC/MS in Qualitative Drug Metabolite Studies; Adducts & Clusters formed in LC/MS; PhotoSpray; Quadrupoles vs. Ion Traps; Quadrupole Ion-Trap Mass Analyzer; Stages of LTQ MS/MS Analysis; TSQ Quantum Technology Demonstration; etc…” For more information see
Neuropsychopharmacology Courses & Lectures
Emerging Methods In Molecular Biology And Genetics; Emerging Imaging Technologies And Their Application To Psychiatric Research; Drug Discovery And Evaluation; Disorders Of Development; Schizophrenia And Related Disorders; Anxiety And Stress Disorders; etc…” For more information see
neurological and psychiatric diseases. On one level, this scientific field seeks to understand how drugs can affect the central nervous system (CNS) selectively to relieve pain, heighten attention, induce sleep, reduce fever or appetite, suppress disordered movement, or prevent seizures. Notably, this is the field that seeks to understand how drugs can treat anxiety, mania, depression, or schizophrenia without altering consciousness…” Examples of “Psychopharmacology: The Fourth Generation of Progress” Categories include
Clinical Analysis of Methods; Transitter Systems: Amino Acids, Acetylcholine, Amines; Central Norepinephrine Neurons and Behavior; Gene Targeting Approaches to Serotonin Receptors; Indoleamines: The Role of Serotonin in Clinical Disorders; Peptides; Introduction to Clinical Neuropsychopharmacology; etc…” For more information see
|
Pharmacogentics & Pharmacogenomics Databases, Lectures, Lessons, etc.
relationships among drugs, diseases and genes, including their variations and gene products. Our mission is to catalyze pharmacogenomics research…”
Pharmacokinetics & Biopharmaceutics
Analysis of Urine Data; Intravenous Infusion; Routes of Drug Administration; Pharmacokinetics of Oral Administration; Bioavailability Studies; Physiological Factors Affecting Oral Absorption; Physical-Chemical Factors Affecting Oral Absorption; Multiple IV Bolus Dose Administration; Multiple Oral Dose Administration; Routes of Excretion; etc…” For more information see
Multiple IV bolus dose administration; Multiple oral dose administration; Drug metabolism; Drug distribution; Multi-compartmental pharmacokinetic models; Non-linear pharmacokinetic models; Clinical applications of pharmacokinetics; Optimal sampling; etc…” For more information see |
Radiopharmacy & Radiopharmacology Related Centers FOR RADIOLOGY ATLASES, CASES, COURSES, DATABASES, JOURNALS, TEXTBOOKS, LESSONS, VIDEOS, ETC. SEE THE
Dosimetry Databases & Calculators
medicine procedures, based on literature reported values. Individual organ doses and total body effective doses are given for these specified…” Medical Procedure Radiation Dose Calculator INPUT Values include:
Skull Radiographic; CT Head Scan; Abdominal X-ray…” Nuclear Medicine Scans
Co-57 Cyanocobalamin, IV No Carrier; Cr-51 Sodium Chromate RBC’s etc…” For more information see
with radioactive materials…” Radiation Dose to the Skin From Various Beta Emitters Calculator INPUT Values include:
Iodine 31, Cobalt 60 or Cesium 137); Select Personal Protective Equipment (PPE)
Radioactivity Concentration; Volume Spilled; Time Spill Contacted Skin or Clothing…” For more information see the |
Veterinary Related Centers FOR VETERINARY ATLASES, CASES, COURSES, DATABASES, JOURNALS, TEXTBOOKS, LESSONS, VIDEOS, ETC. SEE THE Examples of Veterinary Pharmacology Courses
For more information see the
Pharmacokinetic Models; Pharmacokinetic Constants; Therapeutic Drug monitoring: Aminoglycosides, Digoxin, etc…” Antimicrobials
Prophylaxis; Detailed Susceptibilities; Antimicrobial Tables; etc…” Glucocorticoids
Pharmacodynamics; Systemic Effects of Glucocorticoid; Glucocorticoids as Drugs; Glucocorticoid Replacement Therapy; etc…” Non-Steroidal Anti-Inflammatory Drugs (NSAID)
Mechanism(s) of Action; Pharmacokinetics; Dosing; Toxicity; etc…” Cardiovascular Therapeutics
Positive Inotropes; Vasodilators; Diuretics; etc…” Gastrointestinal Therapeutics
Control of Emesis; Central-acting antiemetics; etc..” Respiratory System; For more information see |
Statistics Related Centers FOR MORE THAN “100” DRUG CALCULATORS SEE THE FOR MORE THAN “400” STATISTICAL COURSES & CALCULATORS SEE THE Pharmacology Statistics Calculators, Courses, Lectures, Lessons, etc. Examples of Statistics Courses
on the world-wide web…” VassarStats Statistics Calculators include:
Randomizer Calculator; Simple Graph Maker Calculator; etc…” Clinical Research Calculators
Pascal (Negative Binomial) Probabilities Calculator; Backward Probability Template Calculator; etc…” Distribution Calculators
Poisson Distributions Calculator; Chi-Square Distributions Calculator; t-Distributions Calculator; Distributions of r Calculator; F-Distributions Calculator; etc…” Frequency Data Calculators
Kolmogorov-Smirnov One-Sample Test Calculator; etc…” Proportions Calculators
Significance of the Difference Between Two Correlated Proportions Calculator; etc…” Ordinal Data Calculators
Mann-Whitney Test Calculator; Wilcoxon Signed-Ranks Test Calculator; etc…” Correlation & Regression Calculators
t-Test for Independent or Correlated Samples Calculator; etc…” ANOVA Calculators; ANCOVA Calculators; etc…” For more information see Examples of Calculators
and metabolism, and excretion of drugs…” “…Application of biopharmaceutical and pharmacokinetic theory to clinical problems…” For more information see
Elimination Rate Constant; Time since IV Dose…”
community. Created by scientists for scientists, our intuitive programs provide researchers worldwide with the tools they need to simplify data analysis, statistics and graphing…” Some examples from over “25” Calculators include
used to analyze retrospective case-control studies…”
Desired Confidence Level…”
But note that this calculator does not perform the ANOVA calculations – you must use another program for that…”
|
Leave a Reply